Van de Ven Double Halts The Toffees' Run at New Stadium
The Dutch defender emerged as the first backline player to score twice in a English top-flight match for Tottenham since the Belgian defender in spring 2013.
At a glance
The Spurs defender heads home two times in first half
The home side's defender has goal ruled after VAR review
Pape Matar Sarr nets third in 89th minute
The defeat is Everton's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Spurs extended their unbeaten run in away games in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were undefeated in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after 133 years at the end of last season.
But Spurs captain Van de Ven struck on two occasions from corners in the first half to place their impressive record at risk, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - headed home a third to put the game to bed.
Jake O'Brien thought he had levelled the tally five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a series of fine stops to ensure Tottenham went five matches on the road without defeat in the Premier League.
But the VAR intervened, advising Craig Pawson to review the goal on the pitchside monitor and the official decided that Jack Grealish and the attacker were in offside positions and had impeded with the Spurs keeper.
The win moves the manager's team up to third in the Premier League, a handful of points off north London rivals and table-toppers Arsenal.
The Merseyside club stay in 14th position and are half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven fulfils duties at each end of the field
After a drab midweek performance in the Champions League against the French side, where they mustered a only attempts on target, Frank chose the French striker up front instead of former Toffees player Richarlison.
The new arrival was unable to make much of an impact before being substituted for the substitute after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Defender Van de Ven transformed into an offensive threat to be feared.
Spurs' opening strike came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an unmarked Van de Ven to score.
And Ven de Ven - stepping up as captain in the Argentine's absence - added his next goal in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was just as outstanding in defence, combining well with his defensive colleague as the duo handled excellently with the numerous deliveries sent their way by the opposition.
Toffees breakdown: Everton lacking striker's instinct
The club's new home had been a happy hunting ground, but it seems the freshness may have faded slightly and fans flocked to the gates after the midfielder's third for Tottenham.
The end in Everton's winning streak at home will not be a major concern for the manager, but their striker situation will be.
Beto and Thierno Barry - the Toffees' two established centre-forwards - had netted just a single goal between them before Sunday's outing.
And they were failed to add to that miserable tally on a wet and gloomy night on Merseyside.
Beto's form was epitomized when he chose to bicycle-kick a golden opportunity from near the goal, even with having space and time to readjust for a simpler shot that would have tested the keeper.
The substitute, too, failed to influence the game after coming on for Beto in the 65th minute.
It was not for a shortage of chance. The majority of the home side's offensive moves came through the winger and the forward, who tirelessly delivered dangerous crosses into the Spurs box.
What next for these two sides?
Everton: Moyes' men travel to the Stadium of Light in the top flight on early November at 8 PM.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup match against Newcastle.